sofosbuvir and ledipasvir

Sofosbuvir and Ledipasvir tablets price in India supplier, exporters

At the beginning of 2014, the European Medicines Agency and the Sanitary and Epidemiological Service approved the new “Harvoni” medicine from the American manufacturer “Gilead Sciences”. Its uniqueness consists in the fact that in the composition of 1 tablet two active components simultaneously – sofosbuvir and ledipasvir.

The anti-hepatitis agent can be used as a mono-dependent drug in the treatment of hepatitis C. According to the instructions, “Ledipasvir and Sofosbuvir” tablets are suitable for the treatment of HCV genotype 1 in patients over 18 years of age. During the entire 12- or 24-week treatment cycle, the need for additional medicines, such as “Ribavirin”, “Interferon alfa” and other pegylated interferons, disappears completely. Non-interferon therapy in 99% of cases leads to a persistent virologic response and, as a consequence, to complete healing of patients.

Preparation

After completing the medical tests for new anti-hepatitis drugs, Gilead Sciences has asked the Medicines Committee to approve a new antiviral ligament – “Sofosbuvir and Ledipasvir”.

The preparation “Ledipasvir” refers to inhibitors of NS5A non-structured protein and to “Sofosbuvir” – NS5B polymerases. According to the data announced at the retrovirus study conference, a combination therapy scheme of “Ribavirin”, “Ledipasvir” and “Sovaldi” contributes to the complete destruction of HCV in 100% of patients with genotype hepatitis. “Ledipasvir” and “Sofosbuvir”, without any problems, pass medical tests with both “Ribavirin” and without it.

At the beginning of February 2014, the manufacturer submitted an application to the FDA for the approval of a new “Harvoni” combined drug. After repeating the test drugs, it was found that its efficacy did not even decrease in the treatment of patients who had previously had another type of anti-hepatitis therapy.

Instructions for use

“Ledipasvir and sofosbuvir” is one of the most effective HCV treatment regimens. Taking a pill once a day can reduce the drug’s load on the liver and prevent a deterioration in the patient’s well-being.

When taking medicines, the following information should be considered:

The tablet cannot be absorbed, cut or chewed;
Take your medicine during or after a meal;
Consume the tablet can only be non-carbonated (preferably mineral) water.

According to many experts, the combination of drugs “Sofosbuvir” and “Ledipasvir” is one of the most effective in the treatment of hepatitis. Separately, drugs can not be used to pass monotherapy. That is why the pharmaceutical company “Gilead Sciences” has begun to produce a combined “Harvoni”.

Ledipasvir is prescribed to patients in the following cases;

In the diagnosis of hepatitis C genotypes 1, 4, 5 and 6.

If a patient has the HCV genotype 1 and 4 caused by HIV disease.

If a large number of viruses are found in the patient’s blood.

Composition and purpose of the drug

The tablet contains two active ingredients: sofosbuvir 400 mg and ledipasvir 90 mg.

The instruction for use of the medicine says it can be used when:

  • with HCV previously treated with “Ribavirin” and “Interferon alfa”;
  • viral hepatitis of the first genotype with stage I or 2-1 hepatic fibrosis;
  • double infection of the body with HCV and human immunodeficiency (HIV);
  • HCV of the first genotype, which is accompanied by decompensated cirrhosis.

What is side effect expected?

Some patients who only start using the medicine may notice undesirable side effects:

  • skin bleaching;
  • nausea;
  • back or liver pain;
  • insomnia;
  • fever;
  • headache.

Generic Harvoni

“Harvoni” is quite expensive – more than 1150 dollars per tablet. For passing a full 3-month therapy requires at least 84 tablets, which means treatment will cost a minimum of $ 95,000.

In 2015, Gilead Sciences has agreed to issue pharmaceutical production licenses to other cheaper generic countries. Licensed generic medicines include 400 mg of sofosbuvir and 90 mg of Ledipasvir. From this, it follows that, depending on their effectiveness, they fully correspond to the original “Harvoni” preparation.

Among the best generics in India are:

Name of Medicine                  Manufacturer

Hepcinat-LP                                    Natco Pharma

Ledihep                                            Zydus Heptiza

Myhep LVIR                                     Mylan Pharmaceuticals

Ledifos                                              Hetero Ltd

 

Buy Sofosbuvir and Ledipasvir online from India

The original “Harvoni” is expensive, so at the beginning of 2015 on the world pharmaceutical market, the first analogs of the cheaper drug – “Hepcinat LP”, “Ledifos”, “Ledihep”, appeared.

The first generic was only marketed a year ago in India. They were sold in Mumbai and Delhi. But then they became more affordable, so now they can be safely purchased online via the Internet. However, due to the increase in demand, there was the risk of being caught by “rogue” suppliers.

Therefore, before making an order, you need to make sure the seller is reliable, searching for feedback about it. The supplier should have a license to sell the medicines.

You can buy Sofosbuvir and online ledipasvir directly from us by sending your query through our website. This can be done by phone or by completing an online survey form on our website.

If you have any questions, please contact us. We’ll try to solve it.

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