sofosbuvir and daclatasvir

Treatment of hepatitis C with Sofosbuvir and Daclatasvir “Hepcinat Plus”

Sofosbuvir and Daclatasvir treatment of viral hepatitis C before 2011 depends on the interferon mixture with Ribavirin, however, the consequences of long-term treatment were frustrating – about 45% of the restoration. In particular, the symptoms of the use of these drugs have severely destroyed the image. Patients complained of illness, hair loss, and, most importantly, deep depression, until suicide attempts.

In 2011, an innovative breakthrough was made, giving people who suffer from hepatitis C the chance to recover without serious consequences. This breakthrough was the latest antiviral drugs – Sofosbuvir and Daclatasvir. The effectiveness of the combination of drugs is up to 90-100%. Numerous clinical trials have made it possible to conclude that the use of these drugs is not only effective but also safe. Sofosbuvir and Daclatasvir cause negligible reactions in their treatment.

Mechanism of action

Daclatasvir is a drug that has a specific effect on hepatitis C virus RNA. The mechanism of action is based on inhibition of the NS5A protein, which is responsible for the hepatitis C virus replication process. In this case, virion assembling – the viral particle containing nucleic acid (RNA) and capsid (envelope) is blocked. In other words, it can be said that daclatasvir reduces the number of peripheral blood viruses, i.e. reduces viral load. The antiviral effect is directed against four genotypes of the virus.

The drug is administered orally. The product is available in doses of 30 mg and 60 mg. The tablet is recommended to be taken once a day without combining it with the diet. The medicine is not chewed, washed with plenty of water. Excretion of the active substance occurs through the kidneys. The duration of treatment depends on the genotype of the virus and the treatment schedule.

Sofosbuvir is an NS5B RNA-dependent RNA polymerase inhibitor that is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the analogous uridine analog triphosphate analog (GS-461203), which can be incorporated into HCV RNA by NS5B polymerase and acts as a chain terminator.

The drug is used once daily, orally, at a dose of 400 mg. The tablet cannot be chewed because it tastes bitter. Get the product to be combined with food, drink plenty of liquid. It is very important to use the medicine according to the schedule at regular intervals at the same time. If, for whatever reason, the receipt of funds did not take place in time and is exceeded for less than 12 hours, you can drink a pill. If more than half a day has passed, then the next dose should be taken at the usual time.
The combination of these drugs is the most effective of the existing ones. The antiviral effect is even in the treatment of hepatitis C genotype.

Sofosbuvir 400 mg and daclatasvir 60 mg for 3 months. The effectiveness of the treatment is 100% of the cases of healing.
In the second genotype, daclatasvir + sofosbuvir is given in a standard dose for 6 months. Efficiency is 100%.

Treatment regimen and duration of treatment

The course of treatment is designed for a period of twelve or twenty-four weeks. The tables provide detailed therapeutic schemes.

Tabel 1

Patient groupSchemeDuration of treatment
Genotype 1Sofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

12 weeks

12 weeks

Genotype 1 (with or without cirrhosis)Sofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

24 weeks

24 weeks

Genotype 1 + HIVSofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

12 weeks

12 weeks

Genotype 1 with unaffected therapySofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

24 weeks

24 weeks

Tabel 2

Patient groupSchemeDuration of treatment
Genotype 2Sofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

12 weeks

12 weeks

Genotype 2 (with or without cirrhosis)Sofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

24 weeks

24 weeks

Genotype 2 + HIVSofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

12 weeks

12 weeks

Genotype 2 with untreated therapySofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

24 weeks

24 weeks

Tabel 3

Patient groupSchemeDuration of treatment
Genotype 3; 4Sofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

12 weeks

12 weeks

Genotype 3; 4 (with or without cirrhosis)Sofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirină

24 weeks

24 weeks

Genotype 3; 4 + HIVSofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

12 weeks

12 weeks

Genotype 3; 4 with untreated therapySofosbuvir + Daclatasvir

Sofosbuvir + Daclatasvir + Ribavirin

24 weeks

24 weeks

List of Generic Medicines

Generic effective with the same structure is presented below.
The analogs of Sofosbuvir (Sovaldi) and Daclatasvir (Daklinza) are:

Sovihep + Dacihep
Hepcinat + Natdac
Sofovir + Daclahep
Myhep + Mydekla

A composition of generic products and their excipients

Hepcinat (Sofosbuvir) is produced as tablets. In the middle of the capsule contains the active substance – sofosbuvir (400 mg). The purpose of Sofosbuvir is the treatment of hepatitis C, which occurs in a chronic form.

Natdac (Daclatasvir) is a generic product, also manufactured in India. Natdac tablets also contain similar drug-containing medicines containing daclatasvir (60 mg).

The Daclatasvir therapy schedule is usually combined with Sofosbuvir and other antiviral agents: it all depends on the characteristics of the disease.

What can be the negative consequences of using Sofosbuvir and Daclatasvir?
Compared to all existing treatment regimens, Sofosbuvir and Daclatasvir have a minimal amount of side effects.
The most common side effect, developed in about one patient in 10, is:
1. Headaches.
2. Asthenic syndrome.
3. Nausea.

Side effects that occur in less than one patient out of ten are as follows:
1. From the gastrointestinal tract: loss of appetite, diarrhea or constipation, bloating, abdominal pain.
2. From the central nervous system: a bad dream, dizziness, walking instability, anxiety, increased excitability.
3. Anemia.
4. Pain in the muscles and joints.
5. Dry skin.

It should be noted that when patients are given concomitantly with Sofosbuvir, Daclatasvir, and Amiodarone, patients develop severe bradycardia. In an independent study, there have been cases of installing the pacemaker to provide sufficient cardiac function.
Receiving funds from hepatitis is done strictly under the supervision of a physician. If you have any symptoms, tell your doctor about this.
It is not recommended to discontinue treatment with Sofosbuvir and Daclatasvir if there is a “side effect”. In addition, tablets should be taken strictly in time to maintain a sufficient concentration of the active substance in the blood.
For the treatment of hepatitis C, the combination of Sofosbuvir and Daclatasvir is used. This treatment scheme provides faster and more effective results compared to other medicines. Generic Indians are very effective in combating pathology, as evidenced by many clinical trials. The treatment regimen is determined by the hepatologist, taking into account the genotype of the disease and the individual characteristics of the patients. Purchase medications should be checked only by suppliers who have a good reputation.

Where to buy Sofosbuvir and Daclatasvir?

There are two options for buying medicines for hepatitis C treatment in India.
1. Purchase the original American medicines “Sovaldi” and “Daklinza” in pharmacies in Romania. Minus is a high cost, much higher than wages, and is not available to most Romanians.
2. Order generic direct from India, Egypt or China at online pharmacies.
It’s a better way to buy Indian drugs because India is one of the few countries where the drug manufacturing process is strictly controlled by the American company “Gilead”.
When choosing a company and site for an order, you need to make sure that the points are given below;
The company should have a license to sell drugs.
You need to make sure the supplier is reliable.
Examine your reviews carefully.
You do not immediately advise to buy the doctor’s advice because recommendation prices may be significantly higher than the average market value.
.
By ordering medicines in our company you will only get original generic and strong support from our executive customer and guidance for the entire ordering process.

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