What is the price of Harvoni tablets in US, India (Updated), UK, Egypt and Europe

Harvoni tablets application instructions

Hepatitis C is a disease that is increasingly common in the history of enough young people. It is impossible to protect against infection, a working vaccine against this most serious disease in the world. However, new drugs are well struggling with the symptoms of this disease. Harvoni tablets are one of the most reliable drugs of the new generation.

Where to buy Harvoni tablets and what is the price of the drug

For the treatment of hepatitis C, Harmony is used most often abroad. It has been approved for use in major clinics in Israel, the United States, and Europe. However, at the moment it cannot be found in pharmacies of the CIS countries. Here you can buy the drug “Harvoni tablets” in private clinics that have a manufacturer’s certificate. Deliver it from European countries, most often from Germany.

The price of Harvoni tablet is quite high around the world. For example, in Germany, a course of treatment with this drug costs about 20 thousand Euros, and in the United States – about 25 thousand dollars a month. “12 weeks of treatment” for Harvoni in Israel for insurance costs about 90 thousand dollars.

Like many other new and expensive drugs, Harvoni generic has its own copies – generics. They are made mainly in Bangladesh. “Lezovir – C”, as well as “Twinvir” allows you to undergo a course of treatment to a wide range of patients. Asian firms are soon planning to enter the European market with cheap Harmony generics against hepatitis C. You can buy Harvoni tablets on the official online store of the supplier-exporter by following the link below:

The composition of the drug Harvoni

Today Harmony medicine is the best way to fight hepatitis C medicine of the first genotype. The uniqueness of this type of treatment is that the patient does not need to add either ribavirin or interferon to the therapy. This is the third drug in the world, the clinical effect of which was confirmed at the conference devoted to retroviruses in 2013.

This medicine was developed and patented by the American biotechnology company Gilead Sciences in 2014. Harvoni tablet has a diamond shape, orange color and is covered with a special glaze. The active ingredient is “Ledipasvir 90mg and Sofosbuvir 400mg”

The combination of these components has a strong antiviral effect that does not leave the hepatitis C virus a chance to replicate. Additional substances include: lactose monohydrate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, copovidone

The glaze of this drug consists of a number of substances, including talc, macrogol and titanium dioxide.

Harvoni Tablets Brand Name

  • Hepcinat LP  (Manufactured by Natco)
  • Ledifos            (Manufactured by Hetero)
  • Ledihep          (Manufactured by Zydus Cadila)
  • Myhep Lvir   (Manufactured by Mylan)
  • Ledikast   (Manufactured by Aprazer)

The effectiveness of the treatment of hepatitis C with Harvoni

When the main components of the drug Harvoni enter the patient’s body, they begin to block the enzymes responsible for the replication of the hepatitis C virus. This treatment has been repeatedly tested empirically.

The test involved more than 1,300 people with hepatitis C. All participants divided into two groups. Representatives of one group have already been treated, the second – just started. The experiment lasted about twelve weeks.

The first group was given to use the drug Harvoni, as well as ribavirin. The second also received Harvoni, but without ribavirin. The goal of the scientists was to prove the efficacy of their invention and the clinical result after a full course of using the medicine.

The results were as follows: Already after 8 weeks, 95% of the people who were first treated for the ailment, fully recovered.  After 12 weeks, their number increased to 97%. 99% of people who came to the experiment with cirrhosis fully recovered after 12 weeks. Thus, the years of work on the drug were not in vain, the effectiveness of the drug without the use of ribavirin was proved. Harmony’s feedback was mostly positive, but some experienced a side effect of a headache and nausea.

Indications for use Harvoni

The drug Harvoni tablet is necessary for patients suffering from hepatitis C of the first genotype. This type of virus is the most common. However, his treatment so far has been incredibly difficult. Adapting, the virus produces specific immunity to antibiotics.

In total, the hepatitis C virus has six genotypes, and they, in turn, have subgroups. Such a number of “mutations” makes the virus resistant to our immunity and various medications.

During the diagnosis, it is very important to determine the genotype of the virus, this will help to quickly choose a therapy. The drug Harvoni tablets prescribed to patients who have cirrhosis, as well as without it. In more than 90% of cases of hepatitis C, the first genotype develops a chronic form.

Only 10-15% of people are cured of a viral disease independently and completely, the rest are carriers and dangerous for other people. Most often, patients are prescribed interferon as the main medication. However, it has a number of contraindications, as well as side effects (bronchospasm, edema, anaphylactic shock).

Harvoni tablet can be included in therapy for people who have only been diagnosed and begin treatment. It will also be effective for those who have unsuccessfully fought this disease for years. It can be applied to those who have allergic reactions to common treatments for ribavirin, as well as interferon.

Harvoni tablet is prescribed if the patient is over 18 years old, and his body mass index is more than 18 kg per. The concentration of viral RNA should be more than 10,000 IU in the patient’s plasma.

Contraindications to the use of Harvoni

Like any drug, Harvoni has a number of contraindications. During blood donation for the presence of hepatitis C RNA, as well as the genotype of the virus, the attending physician should ask the patient for allergic reactions to some components of the drug.

Contraindications to Harvoni are also:

Pregnancy and breastfeeding.

Using another medicine, composed of Sofosbuvir.

There is a risk that there will be an excessive amount of this substance in the patient’s body, which leads to chemical poisoning.

Using drugs with tenofovir.

Taking medications containing tipranavir and carbamazepine.

These substances and components can neutralize the antiviral effect of the drug. Before you begin a course of treatment, you need to be tested for kidney or liver failure. Such diagnoses often accompany hepatitis. The treatment of Harvoni tablet is possible in this case, however, under the strict supervision of the therapist and narrow specialists.

Contraindications

It is worth taking a responsible approach to the choice of contraception since pregnancy is not recommended during the treatment period. Unknown risks of influence on the fetus. It is also necessary to abandon breastfeeding, as Harvoni tablets penetrate with the milk into the body of the baby. Doctors never prescribe a drug to children under eighteen years of age, since its effect on the fragile organism has not yet been studied.

Side effects from using Harvoni tablet

Harvoni’s side effects occur infrequently but can occur. As a rule, these are migraines and headaches, fatigue and lethargy, and allergic manifestations (rarely).

If you are using Harmony for the first time, you should be careful and listen to your own body. Suspicions should cause symptoms such as shortness of breath, swelling, severe itching in the body. In such cases, therapy is interrupted instantly. After consulting with a virologist, a new drug regimen is being compiled.

Many physicians who conduct patients with hepatitis C notice typical effects after starting to use the medication (malaise, insomnia, lethargy). However, do not panic. An experienced doctor will be able to assess the risks of using Harvoni and advise an individual regimen.

When using Harvoni tablets with ribavirin, the risks of side effects are much higher. Cirrhosis can also be a factor in the development of complications, but there are no direct contraindications. In 90% of cases, the drug is tolerated calmly and gives a relatively quick recovery.

Harvoni does not affect concentration, so you can drive a car during treatment. However, it is worth being alert: fatigue of the body can adversely affect the functioning of the brain.

There is no need for any special changes in the course of Harvoni’s intake for the elderly after 65 years. They have prescribed the usual dose of medication.

admin

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top